PolypStim Technology

What is the candidate PolypStim technology designed to do?

Note – Investigational use only. Not yet proven safe or effective in statistically significant controlled clinical trials. Not available for sale. Available for investigational use only in countries where proper regulatory clearances have been received.

  • The bioelectric stimulation and scanning lead is directed to the location of the growth to be treated via standard endoscopes normally use for biopsies or minimally invasive surgical removal.
  • Scans, reads and analyzes polyps, cysts and fibroids to determine if cancerous or not without a biopsy and to determine communication method signals.
  • Customizes a bioelectric treatment sequence designed to (1) jam communication, (2) stop cell division, (3) shrink and/or eliminate growth, (4) change surface proteins so the person’s body attacks growth – immunotherapy, (4) change surface electrical charge, (5) starves growth of blood supply – anti-angiogenic proteins, (6) heal and regenerates tissues post growth shrinkage or eradication, (7) manage and modulate inflammation.
  • If polyp, cyst or fibroids are removed with standard minimally invasive surgery methods the bioelectric stimulation sequences are designed to accelerate healing, reduce bleeding and provide pain relief.
  • Bioelectric stimulation lead may also deliver harmonic resonant vibration signals designed to burst growth cells like an opera singer shatters a wine glass, if desired.
  • The pacing infusion lead may also be used to deliver a proprietary PS-15 cocktail comprised of stem cells, growth factors, amniotic fluid, PRF, selected exosomes, selected alkaloids, selected Micro RNAs, engineered hydrogel, mucosa matrix and oxygenated nano particles as a secondary treatment methodology in difficult cases.


A therapeutic endoscopic procedure provides treatment that is carried out via the endoscope. A procedure, which starts as a diagnostic or screening endoscopy, may become a therapeutic endoscopy depending on what is visualized during the procedure. An example is the finding and removal of polyps during a colonoscopy or treating a peptic ulcer that is bleeding. Bioelectric scanning is used to profile the growth and then an external microprocessor designs a customized bioelectric signaling sequence to stop the growth and heal the organ while minimizing pain and bleeding. These bioelectric signals may serve to jam communication, change surface proteins and charges to illicit an immunotherapy response, directed stop cell division, starve growth blood supply, harmonically burst growth cells with resonance vibrational energy or manage and modulate inflammation or any combination of the above.


Some of the therapeutic endoscopic services being provided today worldwide include:

  • Endoscopic hemostasis
  • Foreign body removal
  • Polypectomy
  • Stenting
  • Variceal banding
  • Endoscopic mucosal resection
  • Endoscopic ablation


Our specialists have practices dedicated to performing the following advanced endoscopic procedures:
Endoscopic Retrograde Cholangiopancreatography (ERCP) – ERCP is a technique that combines the use of endoscopy and fluoroscopy to diagnose and treat certain problems of the biliary or pancreatic ductal systems.
Endoscopic Dilation – Esophageal dilation is a procedure that allows dilatation, or stretching, of a narrowed area of the esophagus.
Endoscopic Ultrasound (EUS) – Endoscopic ultrasound (EUS) is a technique using sound waves, known as ultrasound, during an endoscopic procedure to look at or through the wall of the gastrointestinal tract. This technique allows physicians to see organs and structures not typically visible during traditional endoscopy procedures, such as the layers of the gastrointestinal tract wall, the liver, pancreas, lymph nodes, and bile ducts.
Percutaneous Endoscopic Gastrostomy (PEG) – Percutaneous endoscopic gastrostomy (PEG) is a endoscopic procedure in which a flexible tube is placed into a patient’s stomach and/or small intestine to allow nutrition, fluids and/or medication to pass directly into the stomach or small intestine when a patient is not able to meet his or her nutritional needs orally due to a medical condition.

What are Polyps?

Polyps are abnormal tissue growths that most often look like small, flat bumps or tiny mushroomlike stalks. Most polyps are small and less than half an inch wide.
Polyps in the colon are the most common, but it’s also possible to develop polyps in places that include:

  • ear canal
  • cervix
  • stomach
  • nose
  • uterus
  • throat

Most polyps are benign, meaning they’re noncancerous. But because they are due to abnormal cell growth, they can eventually become malignant, or cancerous. Your doctor can help determine if the growth is a polyp by performing a biopsy. This involves taking a small sample of tissue and testing it for the presence of cancerous cells.

Treatment for polyps depends on their location, size, and whether they’re benign or malignant.

Applications include

  • Nasal
  • Colon
  • Vocal chords
  • Throat
  • Uterus
  • Cervix
  • Ovaries
  • Stomach
  • Ear canal
  • Skin
  • Kidneys
  • Pancreas
  • Pineal gland
  • Teeth
  • Bladder

What are the symptoms of polyps?

Each type of polyp can cause unique symptoms based on location. Below are some common polyp types, their locations, and symptoms.

Type of polyps Location Symptoms
aural ear canal loss of hearing and blood drainage from the ear
cervical cervix, where the uterus connects to the vagina typically no symptoms, but can include bleeding during menstruation (heavier) or sex, or an unusual discharge
colorectal (colon) large intestine, colon, and rectum blood in stool, abdominal pain, constipation, diarrhea
nasal nose or near sinuses similar to the common cold such as headache, nose pain, loss of smell
gastric (stomach) stomach and stomach lining nausea, pain, tenderness, vomiting, bleeding
endometrial (uterine) uterus, usually uterine lining infertility, irregular menstrual bleeding, vaginal bleeding
vocal cord (throat) vocal cords hoarse and breathy voice that develops over a few days to several weeks
bladder bladder lining blood in urine, painful urination, frequent urination
Most colon polyps are noncancerous and do not often cause symptoms until they are in their later stages. But like gastric polyps, they can develop into cancer.

PolypStim Mettler 740 Stimulator

Programmed with patented and patent pending protein expression bioelectric signals

PolypStim amongst other mechanisms of action is designed to regulate and modulate ion transport to and from polyps to eradicate their growth and to reduce risk of transformation into cancerous tumors.

What causes polyps?

The causes of polyps can vary based on their location. For example, throat polyps are usually a result of an injury from shouting loudly or damage from a breathing tube. And sometimes doctors can’t determine the cause of polyps.
Some known causes include:
Polyps grow through rapidly dividing cells, which is similar to how cancer cells grow. This is why they can become cancerous, even though most polyps are benign.

Risk Factors

What are the risk factors of polyps?
Men and people who smoke have a higher risk for bladder polyps. Women over 40 years of age and women who have had children are more likely to develop polyps in the uterus.
For cervical polyps, the risk increases in women over 20 years or age and women who are premenopausal.
People who habitually stress their vocal cords or have acid reflux have a higher risk for throat polyps. But there are no known risk factors for aural polyps.
Talk to your doctor about your individual risks for polyps if you are concerned about a specific type.

Risks for colon polyps

For colon polyps, the risk factors include:
  • eating a high-fat, low-fiber diet
  • being over 50 years of age
  • having a family history of colon polyps and cancer
  • using tobacco and alcohol
  • having an intestinal inflammation disorder like Crohn’s disease
  • being obese
  • not getting enough exercise
  • having type 2 diabetes that isn’t well-managed
African-Americans are also at a higher risk of developing colon polyps.

Risks for stomach polyps

The risk for stomach polyps increases with the following:

Risks for nasal polyps

Nasal polyps are more likely to develop in people who experience the following conditions:

How are polyps diagnosed?

Your doctor will perform a physical exam and ask questions about your symptoms and medical history. If your doctor suspects polyps, they will typically use imaging like X-rays, ultrasound, or a CT scan to see the affected area, which can help confirm a polyp’s presence and size.
When you have a polyp, your doctor may want to perform a biopsy to find out if it is cancerous.

How are polyps treated?

Some polyps won’t require treatment, especially if your doctor says they aren’t harmful. Throat polyps typically go away on their own with rest and voice therapy. Others may be surgically removed as a precaution against the future development of cancer.
Treatment for polyps depends on a number of factors, including:
  • whether or not the polyps are cancerous
  • how many polyps are found
  • where they are located
  • their size
In the case of colorectal polyps, a doctor may remove the polyps during a colonoscopy. A colonoscopy is when your doctor uses a thin tube with a camera attached to look at the insides of your rectum and large intestine.
Your doctor may prescribe progestin and gonadotropin-releasing hormone agonists for hormone-related polyps, like cervical and uterine polyps. These drugs will tell your body to create more hormones to shrink or reduce the polyps.
Nasal steroids or corticosteroid treatments may help to treat nasal polyps.
Your doctor will use the least invasive treatment before opting for surgical interventions.

What is the outlook for someone with polyps?

Your doctor will discuss the outlook for your particular diagnosis. The outlook for polyps depends upon the type of polyps, if they are cancerous, and your overall health. Most benign polyps are normally nothing to worry about, but your doctor may suggest removing them as a precaution.

It’s possible for benign polyps to develop into cancerous ones, or interfere with your life by causing infertility from uterine polyps or persistent stuffiness from nasal polyps.

The chance that polyps will reappear is slim, but colon polyps recur in 30 percent of people who have had them removed. Your doctor will recommend follow-up procedures, usually within 3 to 5 years.